Search Button
All News

Subject:Ophthalmos presenting at ISOPT meeting in Rome, Dec 1-3 2016

Ophthalmos presenting at ISOPT meeting in Rome, Dec 1-3 2016

Supplementation with ω-3 fatty acids has been demonstrated to be beneficial for dry Macular Degeneration regression when the blood AA/EPA = 1-1.5 in this mouse model of dry macular degeneration, and could be considered a potential therapeutic regimen for patients with dry AMD.

Dr Tassos Georgiou and his Research team presented the results of the study on dry macular degeneration and omega 3 fatty acids.

The summary of the study: 

• A significant increase in the ONL thickness  (photoreceptor nuclei) observed in  the ω-3-treated group.
• The results are consistent with other studies; in particular, Tuo et al. used double knockout Ccl2-/-/Cx3cr1-/- mice to investigate the effect of an ω-3 PUFA diet. This effect was suggested to occur through a reduction in the AA metabolism, as demonstrated by the decreased pro-inflammatory derivatives (PGE2 and LTB4) (5).
• Our findings indicated a superior effect with regard to photoreceptor preservation and perhaps regeneration because the ω-3-treated group exhibited an even greater ONL thickness than that of younger mice (3-month-old).
• Fatty acid analysis showed reduced pro-inflammatory and increased anti-inflammatory fatty acids in both blood and retina in the treatment groups.
• EPA and DHA retinal levels were higher in the treated groups, suggesting that ω-3 treatment is enhancing retinal function.
• A decrease in the transcript levels of retinal TLR3 and NF-κB was observed in the treatment groups, with a more evident effect in the ω-3 group. Once stimulated, TLR3 is associated with microglia cell activation through production of interleukins and other cytokines via NF-κB regulation (6).
• Therefore, reduction of TLR3 and NF-κB mRNA levels may indicate a reduced profile of microglia activation in the retina and subsequent decrease in the production of inflammatory cytokines.
• A significant decrease IL-18 transcript levels was observed in the ω-3 group. Doyle et al. reported that drusen isolated from donor AMD eyes activates the NLRP3 inflammasome, causing secretion of IL-18 and IL-1β (7), demonstrating IL-18 importance in disease progression. 
• Our findings suggest that treatment with ω-3 fatty acids evidently increases the retinal ONL and has an effect on the resolution of inflammation; although the latter is not the only determinant factor for disease regression.
• Although there is no direct explanation for the pronounced effect of ω-3 treatment with regard to the number of photoreceptors, it is hypothesised that ω-3 PUFAs may involve a stimulatory effect on endogenous retinal stem cells, such as the Muller glial cells and the RPE cell. 

'Supplementation with ω-3 PUFAs has been demonstrated to be beneficial for dry AMD regression when AA/EPA = 1-1.5 in this mouse model, and could be considered a potential therapeutic regimen for patients with dry AMD.'said Dr Georgiou who is the founder and director of Ophthalmos Research and Educational Institute.

These research results will be published soon

Contact Us

Ophthalmos Research & Educational Institute
Morfou 48, Egkomi
2417 Nicosia, Cyprus
Tel.: +357 22 464 344
Fax: +357 22 464 345

Contact our department

Copyright (C) 2017, Ophthalmos   |    Designed and Developed by eBOS Technologies   |    powered by WiseBOS C.M.S